ADVERTORIAL: Introducing Kleresca® for Acne and Skin Rejuvenation

16 Jun 2017

Breakthrough innovations to stimulate skin repair at a cellular level

Kleresca® for Acne and Skin Rejuvenation

Kleresca® is a breakthrough treatment for acne and skin rejuvenation that harnesses the power of BioPhotonics, a unique light conversion system that is designed to stimulate your skin’s own repair at a cellular level. This treatment will significantly and comfortably treat acne and stimulate the tissue’s own repair systems with high safety and efficacy.

It has shown to improve complexion and benefits the appearance by:

  • Treating active acne lesions
  • Inducing collagen production
  • Reducing pore size
  • Eliminating fine lines and wrinkles
  • Reducing signs of acne scars

How it Works

Usability is very simple and the whole procedure only takes 20 minutes. Kleresca®’s innovative BioPhotonic treatment uses multi-LED light combined with a photoconverter gel. The gel allows the spectrum of wavelengths to penetrate into the dermis of the skin to kill bacteria and stimulate the skin’s own repair systems. It can successfully treat acne and encourage the build-up of collagen, supporting the repair of acne scarring and skin rejuvenation and activating the elements of healing in the skin:1,2

  • The gel enables specific wavelengths from the light device to penetrate the dermis and stimulate the tissue’s own repair mechanisms and normalise cellular activity1,3-7
  • Has been associated with collagen stimulation8
  • Stimulates the vascular system, which is known to have a positive effect on collagen production1,3-7,9
The below illustrative representation demonstrates the build-up of collagen with Kleresca®


Before and after collagen build up

Treatment Modality

The gel is mixed and once the skin is cleansed, it is applied and illuminated under a multi-wavelength LED light for nine minutes each session. After the light session, the gel is removed. There is limited-to-no downtime after the treatment. Side effects are minimal and can include, redness, hyperpigmentation and slight discoloration of hair. All side effects are seen where transient. Kleresca® for active acne lesions is administered twice a week for six weeks and for skin rejuvenation the protocol is once per week for four weeks.

The Science In a randomised, multi-centre, split-face trial that investigated the safety and efficacy of Kleresca® in patients with moderate to severe acne, Kleresca® demonstrated high safety and efficacy:6,10

  • 89% response rate (patients with ≥ 1 IGA grade improvement)10
  • 52% of patients with ≥ 2 IGA grades improvement10
  • 33% of patients reached clear or almost clear skin10
  • No serious adverse events reported10
  • All adverse events were transient and did not require any intervention by the clinic4,7

Kleresca® in Your Clinic

In the clinic, Kleresca® is cost effective and easy to use and requires minimal staff support and patient monitoring and trained professionals can administer the treatment. The company will offer partners access to a number of services and will assist with training of clinic personnel, provide medical advice, as well as other relevant training to facilitate the operations and workflow in a clinic. Kleresca® also aims to support practitioners on treatment optimisation, operations and communications on an ongoing basis to further enhance their practice.

Benefits of Kleresca®

  • Kleresca® provides patients with a pleasant, comfortable experience with studies showing high safety and efficacy5,7
  • The light device is compact, easy to manoeuvre and uses simple settings
  • Preparation of the gel is quick and only requires mixing the contents of two jars, which are easily stored at room temperature5,7
  • The treatment is non-invasive and non-abrasive, making it a comfortable experience10,11
  • The gel is well-tolerated as it is not absorbed into the skin10,11
  • The treatment has little downtime and10,11 fits conveniently into a patient’s busy schedule with active treatment time taking only nine minutes5,7
  • No serious adverse events seen in clinical trials5,7 
The use of LED lamp with photoconverter gel
Patient before, 12 weeks after and 33 weeks post-treatment

Lee Garrett’s Experiences Using Kleresca®

Tell us about your new acne and skin rejuvenation treatment?

The new treatment I have introduced to my clinic for acne and skin rejuvenation is called Kleresca®, which is a chromophore gel that is applied to the skin before putting the patient underneath a LED lamp. When I heard about this treatment, which is really popular in countries like Australia, Germany and Italy, I knew I just had to try it on my patients who are suffering from acne and acne scars as these are notoriously hard conditions to treat. There are two different gels, one for active acne and the other for skin rejuvenation. For acne patients, we are looking for patients with moderate to severe acne and for rejuvenation patients they can be anyone from those with acne scars to those with fine lines and wrinkles.

What do you like most about Kleresca®?

Being an acne sufferer myself, who knows what it’s like to be scarred from the acne lesions on my face, I think Kleresca® is a welcome breakthrough for all acne patients. We have many options available to us in terms of rejuvenation treatments, but nothing that’s as non-invasive such as this that still gives such good results. When you are looking at treating patients with acne, the first thing that you have in your contraindications is lesions on the skin. Now, other than chemical peels, you have a treatment that you can apply to patients that have active lesions on their skin. I think that it’s a very good add-on to have in your clinic and there aren’t many treatments out there for acne that can offer what Kleresca® can. Why I say that is because other treatments can be quite painful and quite costly for patients and often once they have had the treatment their acne may come back. With Kleresca®, there is data to suggest that up to 54 weeks post treatment the patient is still spot-free, so I think that is a really good outcome.

What feedback have you had from your patients?

I have been using this in my clinic since February 2017, and initially patients seem a bit apprehensive because they need to be under a lamp for nine minutes, but once they have had the treatment I have found that they are absolutely thrilled with the results. The good thing about this treatment is that it treats all aspects of acne; you can do the acne course first, then you can take the patient onto the skin rejuvenation after the acne has cleared and address any scarring or healing issues. If the patient hasn’t got acne you can take them straight onto the skin rejuvenation gel. As I’ve said, I have suffered from acne so I have tried the rejuvenation treatment myself and what I have noticed is that your skin does feel tighter and much more supple when you touch it; it feels thicker, firmer and more hydrated. I have seen patients go through the whole skin rejuvenation process and we have seen really good results in fine lines and wrinkles and overall skin texture. At my clinic we have acne patients that are on the treatments at the moment and the results so far are very promising. 

Lee Garrett is an independent nurse prescriber and is the director of the Garrett Clinic in Harley Street, London and company security of FreedomHealth. 

Garrett’s understanding of the skin and bespoke treatments has made him one of the most respected practitioners in aesthetics, specialising in acne scarring, facial rejuvenation, dermal fillers, facial reconstructing, anti-winkle treatments and chemical peels.

References

  1. Endothelial cell study, LEO Pharma - Data on file.
  2. Skin insert study, LEO Pharma - Data on file.
  3. PCL-K1005-001-11, LEO Pharma - Data on file.
  4. In vitro release test, LEO Pharma - Data on file.
  5. Kleresca® Acne Treatment Instructions for Use.
  6. Antoniou, C.e.a., Extension trial, LEO Pharma - Data on file. 2013.
  7. Kleresca® Skin Rejuvenation Instructions for Use.
  8. Cho, SB & et al, ‘Non-ablative 1550-nm erbium-glass and ablative 10 600-nm carbon dioxide fractional lasers for acne scars: a randomized split-face study with blinded response evaluation’, J Eur Acad Dermatol Venereol, 2010, 24(8)pp.921-5.
  9. KL-K1005-P001, LEO Pharma - Data on file.
  10. Antoniou, C. & et al, ‘A multicenter, randomized, split-face clinical trial evaluating the efficacy and safety of chromophore gel-assisted blue light phototherapy for the treatment of acne. International Journal of Dermatology’, Int J Dermatol, 2016.
  11. SKR Safety Report, LEO Pharma - Data on file. 

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