Study indicates use of 0.3% A/BPO gel improves severe acne

18 Mar 2016

According to a new study, a combination of adapalene 0.3% and benzoyl peroxide 2.5% gel (A/BPO) has indicated to be superior to a vehicle for the treatment of severe acne.

The data, presented at the 2016 American Academy of Dermatology (AAD) annual meeting, was collected from 252 patients during a randomised, double-blind controlled study. Tanghetti et al conducted the study and compared A/BPO to a vehicle in patients with severe acne. Patients received once-daily treatment for 12 weeks.

The co-primary success points were the percentage of patients rated ‘clear’ or ‘almost clear’ and a change in inflammatory (IN) and noninflammatory (NIN) lesion counts also from baseline to week 12.

There was said to be a treatment success rate difference of 20.1%. At week 12, 0.3% A/BPO was claimed to be superior to the vehicle in percent change in IN (–74.4% vs. –33%) and NIN lesion counts (–72.1% vs. –30.8%). In addition, 0.3% A/BPO was considered ‘safe and well-tolerated among study patients’.

Tanghetti et al said, “The availability of this new treatment option should allow clinicians to better customise severe inflammatory acne management.”


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