Advertorial: Anti-senescence activity of Salvia Haenkei

By Anna Baker / 03 May 2019

Anna Baker BN RGN INP PGCert (App. Clin. Anat.) PGCert (Clin. Ed.) details the science behind Profhilo® Haenkenium® from IBSA Italia

Profhilo® Haenkenium® is a unique and innovative topical formulation which deeply nourishes the skin at a cellular level. This advanced hyaluronic acid complex utilises a patented botanical extract of Salvia Haenkei (0.25%), also known as Prawn Sage, which originates from Bolivia with proven anti-ageing properties. An integrated senescence-screening assay conducted by Matic et al., (2016) outlines findings from more than 3,000 chemical and natural compounds to demonstrate that Salvia Haenkei decreased replicative and UV-mediated senescence in human primary fibroblasts, as well as in a model of in vitro reconstructed human epidermis. Furthermore, the authors report pre-clinical and clinical testing of this extract by performing toxicity and irritability evaluation in vitro to demonstrate the safety of Salvia Haenkei extract for use as a safe and effective anti-ageing skin treatment. 

In addition, phosphatase and tensin homolog protein (PTEN) is a key cellular senescent regulator (Childs et al., 2015), and data from Matic et al., (2016) demonstrate that Salvia Haenkei is a strong inhibitor of senescence driven by depletion of PTEN, decreasing senescence of 50% when compared to untreated control, and by-passing the growth arrest promoted by PTEN loss.

Whilst it is acknowledged that reactive oxygen species (ROS) are produced as a product of normal cellular functioning, excessive amounts can cause detrimental effects (Liochev, 2013). Furthermore, oxidative stress also promotes cellular senescence and premature ageing to the skin (Polefka et al., 2012). Further findings from Matic et al., (2016) describe in-vitro testing of human dermal fibroblasts exposed to hydrogen peroxide, which is a potent inducer of ROS, with the antioxidant activity of Salvia Haenkei assayed immediately after the exposure. The effect of Salvia Haenkei within these cells was similar to N-acetylcysteine (NAC), a known antioxidant compound tested and used to prevent the accumulation of ROS in different inflammatory conditions (Kang et al., 2003). These cumulative data findings from Matic et al., (2016) demonstrate the intracellular levels of ROS, and positive effects of Salvia Haenkei, supporting its efficacy in preventing different types of senescence.

Cocetta et al., (2016) concur that Salvia Haenkei proved to be capable of modulating ROS production in conditions of oxidative stress and that it was able to prevent the increase of Nrf-2 gene expression induced by UVB exposure. The Nrf-2 signalling pathway is a key defence mechanism that is triggered by cells in response to oxidative stress. In addition, the authors noted a protective role of Salvia Haenkei against cellular stress. Cocetta et al., (2016) and Matic et al., (2016) conclude that Salvia Haenkei acts as a gerosuppressant agent, providing protection from free radicals, a cause of oxidative stress and premature cellular senescence, combined with the protective strength of an anti-oxidant.

By contrast, the anti-ageing efficacy of Profhilo® Haenkenium® extrapolated from in vivo data demonstrated statistically significant improvements in redness, wrinkle depth, elasticity and antioxidant potential at day 84 from baseline parameters. Specifically, a reported 9.2% increase in elasticity, as well as a 55.3% increase in antioxidant potential at day 84 from baseline, demonstrating the ability to visibly reduce signs of ageing through improved skin firmness, elasticity and tone.

In addition, Profhilo® Haenkenium® contains a 0.2% hyaluronic acid complex, harnessing the power of different molecular weights to stimulate specific biological functions and responses within the skin (D’Agostino et al., 2017). The high molecular weight hyaluronic acid gives a characteristic protective benefit to the skin, specifically helping to restore and maintain the integrity of the hydrolipidic film (H-HA 800kDA). The low molecular weight hyaluronic acid facilitates optimal skin hydration and hygroscopic properties (L-HA 300kDA). The formulation also contains IBSA’s ultrapure hyaluronic acid, produced with a patented biofermentation process of Streptococcus Zooepidemicus which is ranked worldwide as top high-quality owing to its safety and purity (D’Agostino et al., 2015).

Profhilo® Haenkenium® is available in a 50ml airless pump bottle and is suitable for use immediately after Profhilo® injectable treatment as well as daily use alongside as a treatment to sustain the injectable bioremodelling effects of the patented stabilised hybrid cooperative complexes (NAHYCO™). Ideal for the face, neck and décolletage.

HA-Derma is the exclusive distributor of IBSA’s aesthetic portfolio in the UK and Ireland.

References

  1. Childs B.G., Durik M., Baker D.J. van Deursen J.M. (2015) Cellular senescence in aging and age-related disease: from mechanisms to therapy Nat. Med. 21:1424-1435.
  2. Cocetta V., Catanzaro D., Miolo G., Cadau J., Ragazzi E., Alimonti A., Montopoli M. (2016) Anti-senescence activity of Slavia Haenkei on a skin cellular model AMWC Monaco Poster Presentation.
  3. D’Agostino A., Stellavato A., Corsuto L., Diana P., Filosa R., La Gatta A., De Rosa M., Schiraldi C. (2017) Is molecular size a discriminating factor in hyaluronan interaction with human cells? Carbohydrate Polymers 157(10):21-30.
  4. D’Agostino A., Stellavato A., Busico T., Papa A., Tirino V., Papaccio G., La Gatta A., De Rosa M., Schiraldi C. (2015) In vitro analysis of the effects on wound healing of high and low molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes BMC Cell Biology 16:19 DOI 10.1186/s12860-015-0064-6.
  5. Kang S., Chung J.H., Lee J.H., Fisher G.J., Wan Y.S., Duell E.A., Voorhees J.J. (2003) Topical N-Acetyl Cysteine and Genistein Prevent Ultraviolet-Light-Induced Signalling That Leads to Photoaging in Human Skin in vivo 120(5): 835-841.
  6. Liochev S.I. (2013) Reactive oxygen species and the free radical theory of aging Free Radical Biology and Medicine 60:1-4.
  7. Matic I., Revandkar A., Chen J., Bisio A., Dall’Acqua S., Cocetta V., Brun P., Mancino G., Milanese M., Mattei M., Montopoli M., Alimonti A. (2016) Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay Aging 8:1-17.
  8. Polefka T.G., Meyer T.A., Agin P.P., Bianchini R.J. (2012) Cutaneous oxidative stress J Cosmet Dermatol 11(1): 55.

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