Title: Prospective Single-Site Open-label Study Assessing Safety and Efficacy of Poly-L-Lactic Acid for Temple Volume Loss
Authors: Suleima Arruda, et al.
Published: Journal of Drugs in Dermatology: JDD, January 2026
Keywords: Facial fat, Poly-l-lactic acid (PLLA), Volume loss
Poly-l-lactic acid (PLLA) is an injectable biostimulatory filler used for restoring facial fat volume loss. To evaluate the safety and efficacy of injectable PLLA injections for volume loss in the temples using dual plane injections. Assessments included live ratings and ratings of standardized pictures and ultrasound imaging at weeks 4, 8, 12, and 16 by a trained evaluator. At the 8-week follow-up, there was a statistically significant increase in temporal volume and improvement in skin elasticity in PLLA-treated subjects. Treatment was well-tolerated with minimal self-resolving adverse effects. Ultrasound imaging confirmed that the injection plane was free of vasculature, posing no safety risk. Repeated PLLA treatments in the temporal…
