Pharmacist Miriam Martinez Callejas explores the changing approach to hair loss, from maintaining existing follicles to targeting follicular ageing, regeneration and longevity
As longevity medicine shifts from lifespan to health span, hair loss is increasingly viewed through a regenerative lens; not only preserving viable follicles, but exploring how future therapies may protect, reactivate or generate follicular units.1–3 This marks a move beyond slowing miniaturisation and stimulating regrowth where follicles persist, towards restoring or creating follicular architecture by targeting developmental signals.4–22
‘Hair longevity’ frames miniaturisation, oxidative stress, cellular senescence, fibrosis and altered cycling as part of wider ageing biology.23–27 It asks why follicles lose the ability to sustain normal growth, rather than seeing hair loss only as insufficient hair growth. Lifetime prevalence may reach up to 80% of men and around 50% of women, depending on population and diagnostic threshold.28,29 Its significance extends beyond appearance…
