Title: Non-Surgical Interventions for Reducing Cleft Lip Scars: A Systematic Review and Meta-Analysis
Authors: Neda Eslami, et al.
Published: The Cleft P Craniofacial Journal, November 2025
Key words: Cleft lip, Laser, Scar
This meta-analysis aimed to evaluate the effectiveness of various non-surgical interventions in reducing cleft lip scars. MethodsA systematic search was performed across PubMed, Embase, Scopus, Cochrane, and Web of Science databases up to May 21, 2024. Inclusion criteria encompassed human studies with cohort or randomized controlled trial (RCT) designs that assessed non-surgical interventions for reducing cleft lip scarring following surgery. The reviewed studies primarily focused on botulinum toxin type A (BTA) and laser treatments as non-surgical approaches. Meta-analysis revealed significant improvement in scar appearance with laser therapy (P < .001) but not with BTA…
