A summary of the latest clinical studies
Title: Filler-Induced Lymphatic Compromise: In Silico Modelling of Facial Safety Thresholds and Injection Techniques
Authors: Eqram Rahman, et al.
Published: Aesthetic Plastic Surgery, February 2026
Keywords: Hyaluronic acid, Injection safety, Lymphatic drainage
Soft tissue fillers are central to facial rejuvenation, but their impact on lymphatic drainage is poorly quantified. A multiscale finite element model was built in the AesthetiSIM™ platform to simulate filler-tissue-lymphatic interactions. Seven facial regions (tear trough, malar, nasolabial fold, lips, chin, jawline, and temple) were represented as layered tissue blocks with embedded lymphatic collectors. Hyaluronic acid (HA) was modelled as a hygroscopic hydrogel and calcium hydroxylapatite (CaHA) as a stiffer, non-swelling suspension. Outputs included external pressure on lymphatic collectors, lumen collapse, interstitial flux…
