Hyaluronidases are endogenous enzymes (endoglycosidases) that can depolymerise hyaluronic acid (HA), leading to its degradation. These reduce viscosity of HA which improves tissue diffusion by hydrolysing the disaccharides at hexosaminidic b-1 through b-4 linkages.1,2,3 In the UK, hyaluronidase is licensed for enhancing permeation of subcutaneous and intramuscular injections ranging from local anaesthetics to infusions.3 The use of hyaluronidase has many factors that need to be considered when prescribing for the correction of dermal filler injections. Practitioners require sufficient understanding of the drug and its uses when applying it to aesthetic practice, for both elective and emergency situations.
Hyaluronidase (Hyalase) is available in 1500u of dry power in a glass vial. It is recommended by the Aesthetic Complications Expert (ACE) Group World that should be stored between 2-80C in the…
