Isotretinoin, also known as 13-cis retinoic acid, is a synthetic drug widely known for its treatment of acne.1 The mechanism of action results from isotretinoin-induced expression of apoptotic protein necrosis factor, and a recent review suggests that apoptosis is the culprit for the multitude of well-known side effects of isotretinoin.2 Cell proliferation is regulated by the activation of specific receptors; the nuclear retinoic acid receptors which isotretinoin binds to and activates. Furthermore, it is said to decrease polyamine synthesis and keratinisation, which contributes to its anti-inflammatory and anti-prolific properties.3 The UK licence for isotretinoin was first established in 2001 with strict pregnancy prevention criteria and regular monitoring of blood tests, namely liver function tests and lipids.4 Whilst widely used in acne, there are a number of other dermatological…
